A new study by scientists at the University of York sheds light on the mechanisms behind why men are so much more likely to die from obesity-related diseases compared to women. suggests that it is more common in adipose tissue.
A startling 2016 study found that men are three times more likely than women to die from obesity-related diseases. The study, which looked at health data from about 4 million people, could not explain why obese men are more likely to die prematurely than obese women.
For the past few years, a team of researchers at the University of York has been trying to answer that question. found. Increased vascularity in adipose tissue in this woman was associated with a lower incidence of metabolic abnormalities.
In this new study, we further expanded the process by studying specific endothelial cells in mice that make up the blood vessels of adipose tissue. The goal was to understand the sex-based genetic differences that can be detected in these cells.
This finding revealed distinct genetic differences between male and female mice, especially with respect to genes associated with inflammation. Vascular cells in adipose tissue from male mice displayed proinflammatory genetic markers that were not detected in the same cells from female mice.
“The extent of inflammation-related processes prevalent in men was quite impressive,” said lead investigator Tara Haas of the project. It has been shown to become highly dysfunctional and not respond appropriately to stimuli.”
The mystery became even stranger when researchers examined endothelial cell behavior under laboratory conditions. rice field.
“Even if you take them out of the body where no sex hormones or other factors are circulating, male and female endothelial cells still behave very differently from each other,” Haas added.
The researchers speculate that this difference in epigenetic signatures of endothelial cells between males and females could explain gender-based variation in obesity-related diseases. However, the exact causes causing these fundamental cellular differences in the adipose tissue of male and female animals are still unknown.
“I think it’s not just an obesity-related issue, it’s a broader conceptual issue that also includes healthy aging,” Haas said. “One of the implications of our findings is that there are circumstances in which treatments that are ideal for men may not be ideal for women, and vice versa.”
A new study was published in a journal eye science.
Source: York University
