Two brain pathways identified that govern the urge to itch

Chronic itching is associated with skin conditions such as psoriasis and eczema

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Two distinct brain pathways responsible for itch have been identified in mice. Future therapies that target these neural circuits may improve the treatment of chronic skin diseases such as psoriasis and eczema.

Two types of irritation cause itching. Mechanical stimuli, such as hair tickling the neck, and chemical stimuli, such as allergic reactions. Previously, Martin Golding and his colleagues at the Salk Institute for Biological Sciences in San Diego, California, had identified a brain mechanism underlying chemical itch that…

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