Male contraception has traditionally been limited to condoms and vasectomy, which are not ideal solutions for many reasons. demonstrating a promising new method of regulating and significantly reducing 24-hour fertility.
For decades, women have shouldered much of the responsibility for contraception, thanks to the “pill,” but their male counterparts continue to escape science. too long to take effect, or a combination of these.
But a new drug developed by scientists at Weill Cornell Medicine appears to solve all these problems. Works. This makes the drug his sAC inhibitor, though I’m not sure that pun was intended. Previous studies found that mice and males naturally lacking the gene for sAC were infertile but otherwise healthy, so the team decided to investigate whether blocking it would act as a contraceptive. has embarked on
In tests, scientists gave male mice a single dose of an sAC inhibitor called TDI-11861 and released them with females. This was inevitable, but even after 52 mating attempts, none of the female mice became pregnant. In contrast, the control group impregnated about one third of the females.
Importantly, the researchers said the drug acted quickly, inhibiting mouse sperm within 30 to 60 minutes and remaining 100% effective for up to two and a half hours. After 3 hours, some sperm began to regain motility and returned to full fertility after 24 hours.
If these results apply to humans as well, then this has all the elements of a very useful male pill. You can pop the pills discreetly and cover your nighttime activities with confidence. All in all, after giving the mouse these drugs for her six consecutive weeks, the team found no adverse effects.
That flexibility makes it a more attractive option than other experimental male contraceptives. Other experimental male contraceptives can reduce fertility or take weeks to recover if you want to start trying them for your child. It is less invasive than injecting a gel.
A study was published in a journal Nature Communications.
Source: Weill Cornell Medicine by Scimex
