Migraines and glucose-related features such as fasting insulin and type 2 diabetes are widely understood to be common comorbidities, but scientists are now discovering new treatments developed for debilitating diseases. It has a specific genetic connection that allows us to see regions.
Researchers at the Queensland University of Technology in Australia have discovered a correlated gene that causes so many migraine and headache sufferers to combat blood sugar traits, a double whammy of health problems. It is estimated to affect more than 10% of the population, nearly three times more common in women, and affects more than 17% of women in the United States.
“As far back as 1935, migraines were called ‘glycemic headaches,'” says Dale Nyholt, professor at the QUT Center for Genomics and Personalized Health. “Glycemic characteristics such as insulin resistance, hyperinsulinemia (excess insulin), hypoglycemia (hypoglycemia), and type 2 diabetes are associated with migraines and headaches.”
QUT
The findings came after researchers analyzed the genomes of thousands of migraine sufferers to see if they could identify a genetic link. They performed cross-trait analyzes to identify common genomic regions, loci, genes and pathways and tested for casual relationships.
“Among the nine glycemic characteristics we examined, we found significant genetic correlations between fasting insulin (blood insulin levels) and glycated hemoglobin in both migraine and headache, whereas 2-hour glucose It was genetically correlated with headache only,” said Rafiqul Islam, a postdoctoral fellow at QUT. “We also found an area containing genetic risk factors shared between migraine and fasting insulin, fasting glucose, and glycated hemoglobin, and for headache, glucose, fasting insulin, glycated hemoglobin, and fasting pro We found a region that shares insulin.”
Genetic duplication is an important step in understanding how migraine and its associated glycemic signatures manifest and opens exciting new avenues for medical intervention.
“By identifying genetic correlations and shared loci and genes in our analysis, we have inferred causality, confirmed and improved our understanding of the relationship between migraine, headache and glycemic signatures,” said Nicholt. rice field.
This improved understanding will be welcome news for the millions of people around the world managing these critical health problems.
“Our findings provide a means to develop new therapeutic strategies to manage the glycemic profile of migraine and headache patients, specifically increasing fasting proinsulin levels to protect against headache.” added Islam.
This study was published in the journal human genetics.
Source: Queensland University of Technology
