Antibiotic resistance A new substance has proven useful in treating staphylococcal infections in patients with cutaneous lymphoma. While this is good news for patients, it is also good news for the global threat of antibiotic resistance.
Staphylococcus aureus. It may have been acquired in connection with a wound infection. Most cases get better without treatment, but antibiotics that kill the bacteria may be needed in severe cases. This applies to most of the population. In fact, many of us carry staphylococci in our noses even when we feel perfectly healthy.
However, as more and more staphylococci are becoming resistant to antibiotics (also known as multi-resistant Staphylococcus aureus or MRSA), these infections can be difficult to treat.
What is Antibiotic Resistance?
When antibiotics such as penicillin are unable to prevent the spread of bacteria, the bacteria are called antibiotic resistant. This means that it can spread despite attempts to treat it with antibiotics. Too many antibiotics can cause bacteria to become resistant, so it’s important that antibiotics are only used to treat the most serious infections.
Source: SSI.dk
“Antibiotic resistance is a growing problem, especially globally. When this relatively simple infection suddenly becomes untreatable with antibiotics, the situation becomes serious and sometimes life-threatening,” he said. said Professor Niels Ødum of the LEO Foundation Skin Immunology Research Center at the University of Copenhagen.
Therefore, worldwide, many resources are being invested in combating antibiotic resistance in S. aureus infections, and new studies in patients with cutaneous lymphoma show positive results. A new substance called Staphylococcus aureus has been shown to kill both resistant and non-resistant Staphylococcus aureus without the need for antibiotics.
This finding is good news for patients with weak immune systems, where Staphylococcus aureus infections can be serious and, at worst, fatal. But it also adds to the knowledge we have about other forms of treatment. will be added to
“Staphylococcus can be a huge, sometimes insoluble problem for people with serious illnesses such as cutaneous lymphoma. because we are doing it,” says Niels Ødum, adding:
“That’s why we’re careful not to give everyone antibiotics so they don’t have to deal with more resistant bacteria. It’s important to find
A new substance may be the answer
In some patients, Staphylococcus aureus causes cancer exacerbation. Also, sometimes the antibiotics seem to work, but that doesn’t mean there aren’t problems.
“We find that high-dose antibiotics in patients with severe infections improve health, skin, and cancer symptoms. Patients experience many adverse effects and are also at risk of becoming infected with resistant bacteria,” says Niels Ødum.
Therefore, treating Staphylococcus aureus can be difficult. In the worst cases, cancer patients can die from infections that doctors cannot treat.
We are careful not to give everyone antibiotics because we don’t have to deal with more resistant bacteria
Professor Niels Odum
This new substance is where endolysins enter the scene as it could be part of the solution to antibiotic resistance like MRSA.
“This particular endolysin is a completely new, artificially produced enzyme that has been improved several times and designed as a new drug,” explains postdoc Emil Paresen, the first author of the study. he adds:
“The great thing about this enzyme is that it is designed to penetrate the wall of Staphylococcus aureus. can.
And that’s why researchers decided to test the new substance. They hoped it could kill both resistant and non-resistant staphylococci.
“We have tested this substance on skin samples from patients and it appears to kill Staphylococcus aureus in patients. I don’t care,’ says Niels Ødum, adding:
“The really good news is that lab tests have shown that endolysins don’t just eradicate Staphylococcus aureus. They also inhibit their ability to promote cancer growth.”
Original: Antimicrobial resistance is a global problem.Now researchers may have found a solution
Than: University of Copenhagen | Faculty of Health Sciences, University of Copenhagen
