DNA may be part of life, but if it’s not repaired regularly in the body, it can lead to diseases that cause some pretty unpleasant deaths. Associated with the formation of serious and life-threatening conditions. It is also involved in our natural aging process. Researchers may now have discovered the key to why DNA is repaired in certain cells and not in others. It’s a series of proteins called the DREAM complex. This finding may have implications for cancer prevention and lifespan extension, but further research is needed.
Our body’s DNA strands are constantly damaged by the stresses of everyday life. In most cases, damage is repaired by natural biological systems. If you’re lucky, you’ll see little impact from the failure and repair process. Apart from the cumulative physical deterioration of aging, of course. .
However, in the case of germ cells, the progenitor cells of eggs and sperm, DNA damage is typically much less than that seen in adult cells. , evolution is thought to have minimized damage to the DNA of these important information carriers.
To elucidate why such differences exist between germ cells and mature somatic cells, researchers at the University of Cologne found that more developed cells contain proteins called DREAM complexes (dimerization partners). I discovered that there is a group [DP]retinoblastoma [RB]Like, E2F and MuvB), germ cells do not.
Previous studies have linked the DREAM complex to gene expression and cancer formation. Hypothesizing that the presence of this complex might somehow inhibit DNA repair in somatic cells, the researchers Nematodemore commonly known as roundworms.
This study confirmed the theory, and scientists found that the presence of the DREAM complex actually limits the number of DNA repair mechanisms present in C. elegans cells. It adheres to a DNA construction plan that contains instructions,” says the study brief. “This prevents them from being produced in large numbers.”
maintenance of vision
In an additional phase of the study, the team had success in mice genetically predisposed to premature aging. By inhibiting the DREAM complex, the researchers were able to reverse the natural damage to her DNA in the animal’s retina, allowing vision to be preserved.
Taking it one step further, the team found that inhibiting the DREAM complex in human cells by chemical means in the lab also improved DNA repair function. I am very happy to hear that. NematodeArturo Bujarrabal, lead author of the study, said:
The team says more research is needed, but the discovery of how the DREAM complex interferes with DNA repair in cells could slow the destruction caused by aging and help prevent a variety of diseases, including radiation sickness from space travel. He added that it could open the door to combat .
Professor Björn Schumacher, Director of the Institute for Genomic Stability in Aging and Disease at the University of Cologne, said: A CECAD cluster of excellence in aging research.
Schumacher was a co-author of a study published in a peer-reviewed journal. Nature Structural and Molecular Biology.
Source: University of Cologne
