Weight loss surgery has proven to be an effective long-term health treatment, but it can be costly, can have many unpleasant side effects, is invasive, and reduces the recipient’s One-third require follow-up surgery or hospitalization within 5 years. Not surprisingly, only about 1% of people with eligible weight concerns actually experience it.
A new study highlights the metabolic benefits of weight loss surgery, particularly its impact on bile acid levels and its role in appetite regulation. (isoUDCA) levels were found to be much lower and associated with increased appetite and worse metabolic levels.
Researchers examined bile acid levels in a group of post-operative patients in Amsterdam and two other general populations without surgery and found that fiber supplements naturally reduced isoUDCA levels. . This opens the door to developing therapies that can mimic appetite reduction and better metabolic function to help people lose weight without invasive procedures.
“Preventing and treating obesity and metabolic syndrome by better understanding the complex interplay of genetics, gut microbiota, and diet in the regulation of bile acid levels and their impact on appetite and metabolic health.” It may be possible to develop new strategies to do so.” Christina Menni, lead author, King’s College London.
It’s not the first time scientists have turned to the gut microbiome for weight loss answers, but researchers at the University of Nottingham, King’s College London, and the University of Amsterdam Medical Center have found a little-understood answer to bariatric surgery. It sheds new light on the benefits. appetite.
Understanding the metabolic mechanisms that lead to anorexia may lead to safe and effective treatments for weight loss. Obesity is associated with serious conditions such as diabetes and heart disease, many of which can be alleviated or even reversed by weight loss.
“Our study shows that specific microbial metabolites are responsible for some of these benefits, and that dietary fiber mimics some of these effects, albeit more modestly. It’s possible,” said co-lead author Ana Valdez of the University of Nottingham. of medicine. “This may aid in the design of nutritional supplementation studies aimed at increasing satiety and improving liver parameters.”
This study highlights how gut microbes play a major role in influencing metabolism and regulating levels of isoUDCA.
“This study highlights that dietary fiber is utilized by specific gut microbes and plays an important role in appetite regulation and metabolism.” The product has great potential to reduce obesity without the need for invasive surgery.”
A study was published in a journal cell report medicine.
Source: University of Nottingham
